Hello Rajesh,
Since you are sure VM is unresponsive on every monday.The best way to trouble shoot this will be via performance snapshot logs
http://kb.vmware.com/kb/1967.It is important that you use the vm-support script to capture performance snapshots when your system is experiencing a performance problem. The script cannot collect useful data otherwise. If the snapshot collection interval overlaps with a time when the virtual machine is not experiencing a performance problem, the result may skew the data collected and can make analysis difficult.
1.Are we running any Back-Up on every Monday?
2.Any replication from Storage Perspective?
3.How long the VM is unresponsive and how is it getting recovered?